Dr.ir. P.L. (Peter-Leon) Hagedoorn

T: +31 15 27 82334
E: P.L.Hagedoorn@remove-this.tudelft.nl


Room C2.
Van der Maasweg 9
2629 HZ Delft
The Netherlands

 

Biography

  • 2007 - present
    Assistant professor in the Enzymology Group, Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology
  • 2003-2007
    Post-Doc in the Enzymology group of Prof. W.R. Hagen ‘The ultimate biocatalytic challenge: activation of small inorganic substrates at ambient conditions’
  • 2002-2003
    Post-Doc (Delft University and Technology) in the group of Dr. H.Y. Steensma and Prof. P.J.J. Hooykaas at the Department of Genetics of Leiden University ‘Recombinant expression of Nar1p in Saccharomyces cerevisiae
  • 2002
    PhD (cum laude) Enzymology, Delft University of Technology, The Netherlands, Prof. W.R. Hagen, ‘Metalloproteins containing iron and tungsten: biocatalytic links between organic and inorganic redox chemistry’
  • 1998
    MSc (cum laude) Molecular Sciences, Wageningen University, The Netherlands

Research interests

  • Development and application of novel methods for metalloproteomics
  • Metal cofactor biosynthesis and metalloenzyme maturation
  • Directed evolution of novel metalloenzymes
  • Read more about Peter-Leon's research interests here.

Teaching activities

  • BSc programme Life Science and Technology: biochemistry (lectures), bioconversion (practical, coordinator), research oriented learning (‘leren onderzoeken’, supervisor)
  • MSc programme Molecular Science and Technology: metals in biology (guest lecturer)

Key publications

  • Bevers, LE, Hagedoorn, PL, Santamaria-Araujo, JA, Magalon, A, Hagen, WR, Schwarz, G (2008). The function of MoaB proteins in the biosynthesis of the molybdenum and tungsten cofactors. Biochemistry, 47, 949-956.
  • Bevers, LE, Hagedoorn, PL, Krijger, GC, Hagen, WR (2006). Tungsten transport protein A (WtpA) in Pyrococcus furiosus: first member of a new class of tungstate and molybdate transporters. J. Bacteriol., 188, 6498-6505.
  • Clay, MD, Jenney, FE Jr., Noh, HJ, Hagedoorn, PL, Adams, MWW, Johnson, MK (2002). Resonance Raman characterization of the mononuclear iron active-site vibrations and putative electron transport pathways in Pyrococcus furiosus superoxide reductase, Biochemistry 41, 9833-9841.
  • Primus, JL, Grunenwald, S, Hagedoorn, PL, Albrecht-Gary, AM, Mandon D, Veeger C (2002). The nature of the intermediates in the reactions of Fe(III)- and Mn(III)-microperoxidase-8 with H2O2; a rapid kinetics study. J. Am. Chem. Soc., 124, 1214-1221.
  • Hagedoorn, PL, Schmidt, PP, Andersson, KK, Hagen, WR, Flatmark, T, Martinez, A (2001). The effect of substrate, dihydrobiopterin and dopamine in the EPR spectroscopic properties and the redox potential of the non-heme iron in recombinant human phenylalanine hydroxylase. J. Biol. Chem., 276, 22850-22856.

 

 

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