Prof.dr. U. (Ulf) Hanefeld

T: +31 15 27 89304

Room C2.
Van der Maasweg 9
2629 HZ Delft
The Netherlands


  • 2016-Present
    Sectionleader Biocatalysis group, Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology
  • 2011-Present
    Professor of Biocatalysis, Biocatalysis group, Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology
  • 2007-2011
    Associate professor, Biocatalysis and Organic Chemistry group, Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology
  • 2000-2004
    Fellowship of the Royal Netherlands Academy of Arts and Science (KNAW)
  • 1999-2007
    Assistant professor, Faculty of Applied Sciences, Delft University of Technology
  • 1993-1999
    Post doctoral research at Imperial College, London, UK (Prof.dr. C.W. Rees); University of Cambridge, UK (Prof.dr. J. Staunton); Delft University of Technology, The Netherlands (Prof.dr. J.J. Heijnen and Dr. A.J.J. Straathof
  • 1993
    PhD Georg-August-Universität zu Göttingen, Germany (Prof.dr. H. Laatsch) and University of Washington, Seattle, Wa., USA (Prof.dr. H.G. Floss)
  • 1990
    MSc Georg-August-Universität zu Göttingen, Germany

Research interests

  • Enzymes in organic chemistry
  • Heterogeneous catalysis in organic chemistry
  • Catalytic reaction cascades
  • Read more about Ulf's research interests here.

Teaching activities

  • BSc and MSc programmes MST and LST: Biocatalysis (LM3731), Katalyse (MST_KAT)
  • International Advanced Course: biocatalysis

Key publications

  • V.Resch, J. Jin, B. Chen, U. Hanefeld Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase? - AMB Express 4:30 (2014 1-7 (online only)
    DOI: 10.1186/s13568-014-0030-2
  • A. Ranoux, K. Djanashvili, I.W.C.E. Arends and U. Hanefeld 5-Hydroxymethylfurfural synthesis from hexoses is autocatalytic ACS Catalysis 3 (2013) 760-763.
    DOI: 10.1021/cs400099a 
  • Ranoux, A, Karmee, S, Jin, J, Bhaduri, A, Caiazzo, A, Arends, I, Hanefeld, U (2012) Enhancement of the Substrate Scope of Transketolase - ChemBioChem 13 (13), p.1921–1931. 
  • Telalovic, S, Ramanathan, A., Fei Ng, J, Maheswari, R, Kwakernaak, C, Soulimani, F, Brouwer, HC, Khuan Chuah, G., Weckhuysen, BM, Hanefeld, U (2011) On the synergistic catalytic properties of bimetallic mesoporous materials containing Aluminum and Zirconium: The Prins Cyclisation of Citronellal, Chemistry - A European Journal, 17 (7), pp. 2077-2088. (open access)
  • Jin, J., Oskam, P.C., Karmee, S.K., Straathof, A.J.J., Hanefeld, U. (2010) MhyADH catalysed Michael addition of water and in situ oxidation, Chemical Communications, 46, pp. 8588-8590.
  • Paravidino, M., Sorgedrager, M.J., Orru R.V.A., Hanefeld U. (2010) Activity and enantioselectivity of the hydroxynitrile lyase MeHNL in dry organic solvents, Chemistry - A European Journal, 16 (25), pp. 7596-7604.  (open access)
  • Telalovic, S., Ramanathan, A., Mul, G., Hanefeld, U. (2010) TUD-1: synthesis and application of a versatile catalyst, carrier, material..., Journal of Materials Chemistry, 20, pp. 642-658. (open access)
  • Holt, J., Hanefeld, U. (2009) Enantioselective enzyme-catalysed synthesis of cyanohydrins, Current Organic Synthesis, 6, pp. 15-37. (open access)

Secondary employment

  • None
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