Prof.dr. W.R. (Fred) Hagen

T: +31 15 27 85051

Room C2.
Van der Maasweg 9
2629 HZ Delft
The Netherlands



  • 2000 - present
    Full professor of Enzymology, Group Leader Enzymology, Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology, The Netherlands
  • 1998 - 2000
    Full professor of Bioinorganic Chemistry (60%) at Wageningen University
  • 1995 - 2000
    Full professor of Physical Chemistry (40%), group leader of Molecular Spectroscopy, Faculty of Sciences, Nijmegen University, The Netherlands
  • 1987 - 1995
    Associate professor of Biochemistry (Wageningen)
  • 1985 - 1987
    Assistant professor of Biochemistry (Wageningen)
  • 1984 - 1985
    Post-Doc (ZWO) at Wageningen University, The Netherlands, in the Department of Biochemistry with C. Veeger on Biochemistry of Metalloproteins
  • 1982 - 1984
    Post-Doc (EMBO and NIH) at The University of Michigan, Ann Arbor, in the Biophysics Research Division with W.R. Dunham and R.H. Sands on Magnetic Spectroscopy of Metalloproteins.
  • 1982
    PhD Thesis “EPR spectroscopy of metalloproteins; with emphasis on respiratory complexes” supervisors E.C. Slater and S.P.J. Albracht, Department of Biochemistry, University of Amsterdam
  • 1977
    MSc Chemistry, University of Amsterdam, The Netherlands

Research interests

  • Metal ions in biological systems: metalloprotein catalysis, structure, function, regulation, biosynthesis, transport, storage, industrial applications
  • Magnetic spectroscopy of biomolecules: theory, applications, and numerical analysis of (bio)molecular EPR spectroscopy
  • Read more about Fred's research interests here.

Teaching activities

  • BSc and MSc programmes: Biochemistry
  • International Advanced Courses: Metals in Biology
  • Supervised 17 PhD’s until 2008

Key publications

  • LE Bevers, PL Hagedoorn, WR Hagen (2008) The bioinorganic chemistry of tungsten. Coordination Chemistry Reviews, in press.
  • WR Hagen (2006) EPR spectroscopy as a probe of metal centres in biological systems. Dalton Transactions 2006: 4415-4434.
  • AF Arendsen, J Hadden, G Card, AS McAlpine, S Bailey, V Zaitsev, EHM Duke, PF Lindley, M Kröckel, AX Trautwein, MC Feiters, JM Charnock, CD Garner, SJ Marritt, AJ Thomson, IM Kooter, MK Johnson, WAM van den Berg, WMAM van Dongen, WR Hagen (1998) The “prismane” protein resolved: X-ray structure at 1.7 Å and multiple spectroscopy of two novel 4Fe clusters. Journal of Biological Inorganic Chemistry 3: 81-95.
  • WR Hagen (1989) Direct electron transfer of redox proteins at the bare glassy carbon electrode. European Journal of Biochemistry 182: 523-530.
  • WR Hagen, DO Hearsen, RH Sands, WR Dunham (1985) A statistical theory for powder EPR in distributed systems. Journal of Magnetic Resonance 61: 220-232.

Secondary employment


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