L.A.M. (Luuk) van der Wielen

T: +31 15 278 2361


Room 1.510
Julianalaan 67
2628 BC Delft
The Netherlands                                                                                                              



  • 2012
    Distinguished Professor for Biobased Economy, Delft University of Technology, The Netherlands
  • 1997-present
    Full professor and (since 1998) Group leader BioSeparation Technology, Department of Biotechnology, Faculty of Applied Sciences, Delft University of Technology, The Netherlands
  • 1997
    PhD Bioprocess Technology, Delft University of Technology, The Netherlands, Prof. K.Ch.A.M. Luyben, ‘A countercurrent adsorptive fluidized bed reactor for heterogeneous bioconversions’
  • 1987
    MSc Chemical Engineering, Twente University, The Netherlands, prof. K.R. Westerterp, ‘Multiplicity of (bio)chemical reactors’

Director of BE-Basic, the public private partnership for Biobased Ecologically Balanced Sustainable Industrial Chemistry since 2010
Scientific director of B-Basic, the private-public consortium for Biobased Sustainable Industrial Chemistry, a focused program within the Netherlands Research Council (NWO-ACTS), from 2004-2010
Visiting Professor at the University of San Carlos, Cebu City, The Philippines, since 2001
Principle Scientist Biotechnology (part-time), Royal Dutch Shell, The Netherlands, 2007

Chair of scientific conferences (ESBES 2002, BPP 2005, RRB 2008)
Member of several national member of several national and European committees, such as the Supervisory Board of the Dutch Separation Technology Institute, of the governmental Platform Renewable Feedstocks, Sustainable Energy Cie of the Royal Netherlands Academy of Sciences (KNAW), Steering Group of the EU Technology Platform Suschem/ Industrial Biotechnology, Advisory Committee BIO4EU (European Commission), Steering Committee BBE (Min LNV) and BioPort (thinktank Rotterdam Climate Initiative), as well as advisor to several national and international industries.

Research interests

  • thermodynamics for biotechnological processes
  • process chromatography on several scales, crystallization and precipitation processes
  • multifunctional bioreactors
  • in-situ-product recovery as well as miniaturized (‘on-chip’) and computational, high-throughput technology for rapid process development
  • process integration for bioenergy, biofuels and biochemicals manufacturing

Teaching activities

  • Separation processes for biotechnological, chemical, bio-energy industries
  • Thermodynamics and transport phenomena
  • Bioprocess design, integration and optimization
  • Supervised 20 PhD's until 2008

Key publications

  • Van Hee, P, Hoeben, MA, Van der Lans, RGJM, Van der Wielen, LAM. Strategy for selection of methods for separation of bioparticles from particle mixtures (2006) Biotechnology and Bioengineering, 94 (4), pp. 689-709.
    (in combination with Wielen, LAM van der, P. van Hee, RGJM van der Lans. Selectieve winning van vaste fermentatieproducten met gereduceerd hulpstofgebruik. NL Patent 1025149, 2005)
  • Schoevaart, R, Wolbers, MW, Golubovic, M, Ottens, M, Kieboom, APG, Van Rantwijk, F, Van der Wielen, LAM, Sheldon, RA. Preparation, optimization, and structures, of cross-linked enzyme aggregates (CLEAs) (2004) Biotechnology and Bioengineering, 87 (6), pp. 754-762.
    (plus associated patent Ottens, M, M Golubovic, LAM van der Wielen. Method of preparing heterogeneous protein aggregates based on co-precipitation of pharmaceuticals and biocatalytic components with a carrier protein. NL Patent 1025723, 2004)
  • Buque-Taboada, EM, Straathof, AJJ, Heijnen, JJ, Van der Wielen, LAM. In situ product removal using a crystallization loop in asymmetric reduction of 4-oxoisophorone by Saccharomyces cerevisiae (2004) Biotechnology and Bioengineering, 86 (7), pp. 795-800.
  • Jensen, TB, Reijns, TGP, Billiet, HAH, Van der Wielen, LAM. Novel simulated moving-bed method for reduced solvent consumption (2000) Journal of Chromatography A, 873 (2), pp. 149-162.
    (in combination with Jensen, TB, HAH Billiet and LAM van der Wielen. Method of substantially continuously separating two compounds using a (simulated) moving bed. UK Patent 2826684.4, 1998)
  • Peet, DJ, Bisschops, MAT, Van Hateren, SH, Van der Wielen, LAM. Albumin recovery with centrifugal adsorption technology (CAT) (2002) Biotechnology and Bioengineering, 78 (3), pp. 237-250.
    (in combination with Bisschops, MAT, LAM van der Wielen and KChAM Luyben. Method for carrying out a treatment in the presence of a centrifugal field and an apparatus therefor. Patent WO97/33687, 1997)
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