Research projects

Arranged chronologically, most recent at the top; finished projects at the bottom of the list.

Finished projects

Pyrococcus furiosus ferritin, iron mineralization process and applications in biocatalysis

K. Honarmand Ebrahimi

Di-oxygen activation by cytochrome c oxidase and cytochrome P450 studied on the microsecond time scale: Different biological roles, similar transient catalytic intermediates?

A. Paulus

Nanoscale electrophoresis: a new technology for biomolecular applications

L.A.M. Pouvreau

Microsecond mixing in nanometer channels

S. Mitic

Tungsten metabolism in Pyrococcus furiosus

L.E. Bevers

Functional genomics of metallobiochemistry in hyperthermo-philes: tungsten dependent protein expression in Pyrococcus furiosus

E. Bol

Functional genomics of metallobiochemistry in hyperthermo-philes: Biochemistry of the iron storage protein Ferritin from Pyrococcus furiosus

J. Tatur

Recombinant expression of metalloproteins from Pyrococcus furiosus

P.L. Hagedoorn

Modeling of biomolecular structures: computational biocatalysis

Y. Zhou

Novel bioreductions by hyperthermophilic microorganisms for the natural, specific and on-line production of fine chemicals

D.J. van Haaster

Cobalt enzymes in hyperthermophilic archaeon Pyrococcus furiosus

A. Niztayev

Elucidating structure-function relationship of Pyrococcus furiosus ferredoxin

M.N. Hasan

Exploration of hydrolases from hyperthermophilic organisms for use as enantioselective catalysts in biocatalytic processes

R.C. Agapay

Development of rapid freeze-quench techniques for studying intermediates in enzymatic reactions of denitrification

F.G.M. Wiertz

Single-enzyme voltammetry

H.A. Heering

Denitrification enzymes from the gram-positive bacterium Bacillus azotoformans


Chemically catalysed synthesis of Furanics from Sugars: an aqueous approach  

A. Ranoux

Preparation, characterization, and application of ferritin-based catalysts. 

D. Sordi

Novel Biocatalytic Eco-Efficient Routes to Chiral Alcohols 

S. Kara

Asymmetric cascade reactions incorporating hydroxynitrile-lyase catalysed C–C bond formation 

J. Schrittweiser

In silico rational engineering of novel enzymes

S.K. Karmee

Combining reactions and separations using ionic liquids and supercritical carbon dioxide

M. Paravidino

2-Cyclohexenone Hadratase from Alicycliphilus denitrificans: discovery and application in the hydration of α,ß unsaturated carbonyl compounds

J. Jin

Enzymatic epoxidations and alcohol oxidations

J. van der Toorn

Novel hydro-lyases as biocatalysts by Directed Evolution

L. Otten

Asymmetric epoxidation of electron rich olefins

P.A. Cherando Pereira

A sustainable, two-enzyme, one-pot procedure for the synthesis of enantiomerically pure α-hydroxyacids

A. Chmura

Catalytic cascade reactions for selective oxidations with benign oxidants

A.J. Miernowska

Combining Cross Linked Enzyme Aggregates with Multicomponent Reactions for the efficient preparation of fine chemicals

M. Paravidino

Enantioselective enzymatic hydrolysis of nitriles

S. van Pelt

Vanadate-phytase as oxidation catalyst

S. Aksu-Kanbak

Calix[4]arene based T1-MRI contrast agents

D. Schühle

A chemo-biocatalytic cascade towards α’, α’-disubstituted hydroxyl amides

J. Holt

Targeting liposomes for application as MRI contrast agent or as PET/SPECT agent

D. Abou

68Ga(III) chelates for application as PET agents

K. Pohle

Lanthanide(III) containing nanoparticles as targeted diagnostic and therapeutic agents

M. Norek

Catalytic cascade reactions for selective oxidations with benign oxidants: Laccase/TEMPO catalysed oxidation of alcohols

I. Matijosyte

Enzymatic kinetic resolution of chiral amines

H. Ismail

Amavadin as an enantioselective catalyst

T. Hubregtse

Catalytic membranes for asymmetric hydrogenation

C. Simons

Inulin based DOTA-p-aminoanilide conjugates as carriers for targeting groups in molecular imaging with MRI

L. Granato

Molecular imaging (PET, SPECT, MRI) with peptide-based Ln(III) chelates

T. Ståhlberg

Chemoenzymatic DKR of secondary alcohols and primary amines

M. Eckert

Synthesis of enantiopure carboxylic acids from nitriles

B. Fernandes

Selective liquid phase oxidation of alkenes using Pd-complexes

A. Brethon

(Bio)transformations in and Solvent Properties of Ionic Liquids

M. Janssen

Asymmetric aldol condensation and directed evolution of aldolases

M.J. Sorgedrager

Vanadium substituted phytase as an oxidation catalyst

M.I. Correia

Chemoenzymatic synthesis of furaneol

A. Romano

Cross-linked enzyme aggregates as stable biocatalysts

W.R.K. Schoevaart

The use of lipases in non-natural reactions

R. Lau

Selective oxidation of alcohols and olefins using molecular oxygen

T. Kodama

Chemoenzymatic synthesis of enantiopure amino acid derivatives

V. Háda

Asymmetric synthesis of chiral carboxylic acids

C. Mateo

Aerobic oxidation of alcohols catalyzed by laccase and nitroxyl radicals

Y-X. Li

Chiral catalysts confined in porous hosts- Synthesis and performance

H.M. Hultman

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