Bioprocess Engineering

The Bioprocess Engineering (BPE; formerly Bioseparation Technology, BST) group aims at developing novel concepts for compact, clean and efficient biotechnological manufacturing processes, starting from the fundamental and quantitative knowledge of biomolecular mechanisms, and integrating advanced technological, theoretical and experimental methods.


The research is organised around the following three coherent themes that cover molecular scale, unit operation scale and process scale, respectively:

  1. High-throughput measurement and modelling of biomolecular properties
  2. Equipment development
  3. Bioprocess Integration

These themes are applied to the production of biopharmaceuticals, nutraceuticals, bio-based chemicals and polymers, and bio-energy.

Within the Department of Biotechnology, the BPE group collaborates in particular with the groups Cell Systems Engineering, Biocatalysis, Analytical Biotechnology and Environmental Biotechnology. The group co-ordinates the BE-Basic consortium, and has a principal role in BSc and MSc programmes Life Science & Technology and in the post-master two-year education programme Designer in Bioprocess Engineering.

Permanent scientific staff
Distinguished Professor Luuk A.M. van der Wielen, Group Leader Henk Noorman Adrie J.J. Straathof Marcel Ottens

Dr. Maria C. Cuellar Soares

Dr. Solange I. Mussatto

Key words
Fermentations, Bioseparations, Chromatography, SMB technology, Biocatalysis, Bioprocess integration, Bioparticles, Crystallisation, Partitioning, Proteins, High-throughput experimentation, Miniaturization, Chip Technologies, In-situ product recovery, Multiphase systems, Biopharmaceuticals, Bio-based chemistry, Biofuels, Scale-up



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