Research projects CSE

Arranged chronologically, most recent at the top; finished projects at the bottom of the list.

For vacancies: see vacancy site of Delft University of Technology

For BSc/MSc: see Student projects page

 

Free energy conservation in Saccharomyces cerevisiae

R. Schumacher

Transport processes in the production of organic acids by Aspergillus niger

F. Lameiras

Subcelllular compartmentation of conserved moieties

J. Zhang

Engineering metabolism of S. cerevisiae for the production of fumaric acid

M. Shah

Anaerobic production of amino acids using S. cerevisiae

H. Cueto Rojas

Dynamics of storage polymers in S. cerevisiae

C. Suarez-Mendez

Redox metabolism and its relation to bioethanol production and ethanol stress

K.M. Bekers

Transient chemical stress in S. cerevisiae and P. chrysogenum

L.P. de Jonge

Escherichia coli redox metabolism for the production of polyhydroxybutyrate

M. Itzel Velasco Alvarez

Analysis of metabolic functionality and regulation of storage accumulating microorganisms under dynamic environments

L. Guedes da Silva

DYNAMICS: Analysis and optimization of industrial microorganisms under dynamic process conditions

E. Vasilakou

   

Finished projects

Only those involved in Metabolic Engineering

               

Anaerobic production of amino acids using S. cerevisiae

2012-2014

A. Goel

Sustainable process for production of succinic acid using Saccharomyces cerevisiae

2012-2014

C.A. Bernal Martinez

Impact of recombinant protein production on the core and energy metabolism of Pichia pastoris growing on glucose: methanol mixtures      

2010-2011 

J. Jorda  

Computational framework for dynamic 13C labeling experiments in micro-organisms for in-vivo kinetic modeling 

2009-2011 

Z. Zhao 

Production of fumaric acid with yeast 

2009-2010 

R.J.W. Brooijmans 

Temperature-dependent kinetic modeling of yeast glycolysis 

2008-2013

A.L.B. da Cruz 

Elucidation and modeling of the in-vivo kinetics of enzymes and membrane transporters associated with β-lactam and  non-ribosomal peptide production in Penicillium chrysogenum   

2008-2012 

A.T. Deshmukh  

Hybrid systems modeling and identification in microbiology

2008-2009

D. Vries

Exploring the metabolome through enzymatic a-specificity

2007-2009

M.J.L. de Groot

Transport of Dicarboxylic acids in Saccharomyces cerevisiae

2006-2011

E. Jamalzadeh

Regulation, transport aspects and degeneration of penicillin biosynthesis in Penicillium chrysogenum

2006-2010

R.D. Douma

Data-driven discovery of metabolic and regulatory network structure

2006-2009

D. Bellomo

Systems biology

2006-2009

S.L. Rossell Aragort

Improving arabinose to ethanol conversion by S. cerevisiae

2006-2008

C. Cipollina

Non-isotopic 13C flux analysis of Escherichia coli

2006-2007

M. de Mey

Quantitative analysis of intracellular metabolites using LC-MS/MS

2005-2010

R. Maleki Seifar

13C labeling studies in the central metabolism of Penicillium chrysogenum

2005-2009

Z. Zhao

Quantitative analysis of relationships between fluxome and metabolome in Escherichia coli

2005-2009

H. Taymaz Nikerel

Towards quantitative metabolomics and in vivo kinetic modeling in S. cerevisiae

2004-2010

A.B. Canelas

Managing complexity of cellular systems: theoretical tools for modeling of metabolic reaction networks

2004-2009

I.E. Nikerel

Application and assessment of experimental methods to study the cytosolic primary metabolism of yeast

2004-2006

R. Costenoble

Development of a bioreactor with integrated on-line sensing for batch and fed-batch cultivation on a 100 μL-scale

2003-2008

M. van Leeuwen

Short term step responses of central carbon and storage metabolism in Saccheromyses cerevisiae: novel minibioreactor and 13c studies

2002-2008

F.O. Aboka

Stimulus response methodology for quantitative model development of central carbon metabolism in S. cerevisiae

2002-2006

M.T.A.P. Kresnowati

Development and application of 13C-labelling techniques

2002-2006

R.J. Kleijn

A dynamic and steady state metabolome study of central metabolism and its relation with the penicillin biosynthesis pathway in Penicillium chrysogenum

2002-2006

U.D.M. Nasution

Robust experimental methods to study in-vivo pre-steady state kinetics of primary metabolism in S. cerevisiae

2001-2005

M.R. Mashego

Development and application of experimental and modelling tools for in vivo kinetic analysis in S. cerevisiae

2000-2004

L. Wu

13C-Labeling technique for metabolic network and flux analysis. Theory and applications

1997-2002

W.A. van Winden

Bioprocess modeling and optimization. Fed-batch clavulanic acid production by Streptomyces clavuligerus

1997-2002

J.A. Roubos

Quantitative physiology of S. cerevisiae using metabolic network analysis

1997-2002

H.C. Lange

Measuring & modelling in vivo kinetics of primary metabolism

1997-2001

D. Visser

Efficient mathematical modelling for bioprocesses

1993-1997

H.J.L. van Can

Mathematical modelling of mammalian cells in suspension culture

1990-1998

B. Romein

State estimation and error diagnosis for biotechnological processes

1987-1991

R.T.J.M. van der Heijden

Methodology on monitoring and modelling of microbial metabolism

1986-1991

H. Noorman

 

 

The group's first paper in the field of Metabolic Engineering was: Van Gulik, W.M., Heijnen, J.J. A metabolic network stoichiometry analysis of microbial growth and product formation (1995), Biotechnology an Bioengineering, 48 (6), pp. 681-698. DOI

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