Student projects

Student projects

BSc and MSc final projects (BEP&MEP) within the Industrial Microbiology research group

Scientific staff: Jack Pronk, Jean-Marc Daran, Pascale Daran-Lapujade and Ton van Maris.

The Industrial Microbiology (IMB) research group aims to understand the metabolic and regulatory networks micro-organisms in the context of existing and novel industrial processes. The underlying, application-oriented objectives are (i) the rational, knowledge-based optimization of existing industrial processes and (ii) the development of new industrial applications of industrial micro-organisms. The most intensively studied organisms in our group are yeasts, ranging from laboratory strains of Saccharomyces cerevisiae to hybrid brewing yeasts and non-Saccharomyces species.

Our research activities occur at the interface of fundamental science and industrial application. Recent highlights involve:

  • novel metabolic and evolutionary engineering concepts to enable the use of S. cerevisiae for ethanol production from agricultural residues (now commercialized by DSM; two large-scale plants in the USA and Brazil have started operation in 2014)
  • quantitative analysis of product formation and gene expression in S. cerevisiae at doubling times of over 500 hours, with the long-term goal of uncoupling growth (= biomass formation) from product formation.
  • unravelling of the complex genome structure of industrial yeast strains used in beer brewing, revealing unexpected variability and dynamics of their genome composition

A broad range of techniques is used within the IMB research group. This includes advanced synthetic biology approaches for strain construction; batch, fed-batch and chemostat cultivation in computer-controlled bioreactiors, intracellular and extracellular metabolite analysis, isolation and functional analysis of organelles, DNA sequencing (in 2014, the group acquired an Illumina MiSeq sequencer), micro-array and RNAseq based transcriptome analysis and protein/enzyme activity assays.

The final projects for BSc and MSc students are an integral part of the front-line research in our group. We welcome students in our group and they provide key contributions to our research - not just by performing experiments but also and in particular by generating original ideas!! To allow for projects that take both your research preferences and the continuously changing research activities in the section into account, information on specific is always given during personal appointments.

Interested? Send an e-mail to Mark Bisschops (M.M.M.Bisschops@remove-this.remove-this.TUDelft.NL) who is the contact person for BSc and MSc projects within our group for any questions or for an appointment.





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