Antonia Denkova

Function Assistant Professor 

Phone  +31 (0) 15-2784471 

Email   A.G.Denkova@remove-this.tudelft.nl 

 

Dr.ir. A.G. Denkova

Room: 02.00.400

RID building 50

Mekelweg 15

2629 JB Delft, The Netherlands

 

 

Research interests

  • ‘hot atom’ chemistry
  • self-assembly of block copolymers
  • design of nano-carriers for the retention of radionuclides for both nuclear diagnostics and systemic radionuclide therapy
  • kinetic stability of metal-ligand complexes

Biography

2009 - present     Assistant Professor, Section Radiation and Isotopes for Health of the department Radiation, Radionuclides and Reactors at the Delft University of Technology.

2004 - 2008         Ph.D. in Chemical Engineering at the Delft University of Technology.

1997 - 2003         MSc in Chemical and Biochemical Engineering, Delft University of Technology.

  

Teaching activities

·         CH 3771 Nuclear Science

·         CH 3791 Nuclear Chemistry

  

Related publications

 

2015

Arranja, A, Denkova, AG, Schosseler, F., Waton, g, Morawska, K, Vlierberghe, S Van, Dubruel, P & Mendes, E (2015). Internationalization of molecular and supramolecular pluronic nanocarriers. 15th Conference of the INternational Association of Colloid and Interface Scientists: Mainz, Germany (2015, mei 24 - 2015, mei 29).

Arranja, A, Denkova, AG, Waton, g, Beekman, F, Schosseler, F. & Mendes, E (2015, juli 14). Molecular and supramolecular pluronic nano-carriers for imaging and therapy: a two (2D) and three dimensional (3D) in vitro evaluation. Lisbon, Portugal, Molecular and supramolecular carriers for imaging and therapy.

Denkova, AG, Kruijff, RM de, Wang, G  , Abou, DS  , Wolterbeek, HT & Mendes, E (2015). Polymersomes for alpha-radionuclide therapy: loading, recoli retention, in-vitro and in-vivo results. In s.n. (Ed.), Fourth International conference on multifunctional, hybrid and nanomaterials, Book of Abstracts (pp. s.n.). s.n.: s.n..

Denkova, AG, Kruijff, RM de, Wang, G  , Abou, DS  , Wolterbeek, HT & Mendes, E (2015). Polymersomes for alpha-radionuclide therapy: loading, recoli retention, in-vitro and in-vivo results. Fourth International conference on multifunctional, hybrid and nanomaterials: Sitges, Spain (2015, maart 09 - 2015, maart 13).

Martinelli, J, Denkova, AG & Djanashvili, K (2015). Effects of neutron irradiation on the organic surface functionalities of nanoparticles. European Molecular Imaging Meeting (EMIM) 2015: Tübingen, Germany (2015, maart 18 - 2015, maart 21).

Martinelli, J, Denkova, AG & Djanashvili, K (2015, juli 15). Effects of neutron irradiation on the organic surface functionalities of nanoparticles. Lisbon, Portugal, Molecular and supramolecular carriers for imaging and therapy. 

Moret, JLTM, Alkemade, J, Oehlke, E, Wolterbeek, HT, Ommen, JR van & Denkova, AG (2015). Nano-structures as novel sorber materials for radionuclide generators. Conference Molecular and supramolecular carriers for imaging and therapy: Lisboa, Portugal (2015, juli 13 - 2015, juli 15).

Santini, C, Arranja, A, Denkova, AG, Schosseler, F., Morawska, K, Dubruel, P, Mendes, E, Jong, M de & Bernsen, M (2015). Effect of different injection routes in tumor accumulation and biodistribution of radiolabeled pluronic P94 unimers. EANM'15 - 28th Annual Congress of the European Association of Nuclear Medicine: Hamburg, Germany (2015, oktober 10 - 2015, oktober 14).

Wang, G  , Hoornweg, A, Wolterbeek, HT, Franken, LE, Mendes, E & Denkova, AG (2015). Enhanced retention of encapsulated ions in cross-linked polymersomes. Journal of Physical Chemistry B, 119, 4300-4308.

2014

Jennings, L, Laan, A, Waton, g, Schosseler, F., Denkova, AG & Mendes, E (2014). In-vitro studies of fluorescent radio labeled micelels for targeted radionuclide therapy. Dutch Polymer Days: Lunteren, The Netherlands (2014, januari 17 - 2014, januari 18).

Kruijff, R de, Wang, G  , Abou, DS  , Mendes, E, Wolterbeek, HT & Denkova, AG (2014). Designing polymersomes for nuclear medical applications. In sn (Ed.), AMBA 2014, Book of Abstracts (pp. 1-1). sn: sn.

Kruijff, R de, Denkova, AG, Wang, G  , Mendes, E, Wolterbeek, HT & Abou, DS   (2014). In vivo study of 111in-loaded polymersomes. In sn (Ed.), 17th Radiochemical Conference, Book of Abstracts (pp. 1-1). sn: sn.

Kruijff, RM de, Wang, G  , Denkova, AG, Abou, DS  , Mendes, E & Wolterbeek, HT (2014). Designing polymersomes for nuclear medical applications. AMBA 2014: Advanced Materials fro Biomedical Applications: Ghent, Belgium (2014, november 18 - 2014, november 21).

Kruijff, R de, Denkova, AG, Wang, G, Mendes, E, Wolterbeek, HT & Abou, DS   (2014). In vivo study of 111in-loaded polymersomes. 17th Radiochemical Conference: Marianske Lazne (2014, mei 11 - 2014, mei 16).

Kruijff, R de, Wang, G  , Abou, DS  , Mendes, E, Wolterbeek, HT & Denkova, AG (2014, november 18). Designing polymersomes for nuclear medical applications. Ghent, Belgium, AMBA 2014: Advanced Materials for Biomedical Applications.

Kruijff, R de, Denkova, AG, Wang, G  , Mendes, E, Wolterbeek, HT & Abou, DS   (2014, mei 11). In vivo study of 111in-loaded polymersomes. sn, 17th Radiochemical Conference, Mariánské Lázne, Czech Republic.

Moret, JLTM, Oehlke, E, Ommen, JR van, Wolterbeek, HT & Denkova, AG (2014). Coating high surface area particles for nuclear medicine. In s.n. (Ed.), Book of Abstracts DPTI Annual Event 2014 (pp. 57-57). s.l.: TU Delft Process Technology Institute.

Moret, JLTM, Oehlke, E, Ommen, JR van, Wolterbeek, HT & Denkova, AG (2014). Coating high surface area particles for nuclear medicine. DPTI annual event 2014: Rotterdam (2014, november 07 - 2014, november 07).

Serra Crespo, P, Denkova, AG, Wolterbeek, HT, Kapteijn, F & Gascon, J (2014). Metal-organic framework for isotope purification. NCCC XV: Noordwijkerhout, The Netherlands (2014, maart 10 - 2014, maart 12).

Wang, G, de Kruijff, RM, Rol, A, Thijssen, L, Mendes, E, Morgenstern, A, Bruchertseife, F, Stuart, MCA, Wolterbeek, HT   & Denkova, AG (2014). Retention studies of recoiling daughter nuclides of (225)AC in polymer vesicles. Applied Radiation and Isotopes, 85, 45-53.

Wang, G  , Denkova, AG, Kruijff, R de, Rola, A, Mendes, E, Thijssen, E, Morgenstern, A, Bruchertseifer, F & Wolterbeek, HT (2014). Determining the retention of recoiling daughter nuclides of 225ac in polymeric nanocarriers. In sn (Ed.), 17th Radiochemical Conference, Book of Abstracts (pp. 1-1). sn: sn.

Wang, G, Denkova, AG, Kruijff, R de, Rola, A, Mendes, E, Thijssen, E, Morgenstern, A & Bruchertseifer, F (2014). Determining the retention of recoiling daughter nuclides of 225ac in polymeric nano-carriers. 17th Radiochemical conference: Marianske Lazne (2014, mei 11 - 2014, mei 16).

Wang, G  , Kruijff, RM de, Abou, DS  , Ramos, NN, Mendes, E, Franken, LE, Wolterbeek, HT & Denkova, AG (2014). Polymersomes as radionuclide carriers: pharmacokinetics in healthy and tumor bearing mice. Dutch Polymer Days: Lunteren, The Netherlands (2014, januari 17 - 2014, januari 18).

Wang, G  , Denkova, AG, Kruijff, R de, Rola, A, Mendes, E, Thijssen, E, Morgenstern, A, Bruchertseifer, F & Wolterbeek, HT (2014, mei 11). Determining the retention of recoiling daughter nuclides of 225ac in polymeric nanocarriers. sn, 17th Radiochemical Conference, Mariánské Lázne, Czech Republic.

Yao, TT, Denkova, AG & Warman, JM   (2014). Polymer-gel formation and reformation on irradiation of tertiary-butyl acrylate. Radiation Physics and Chemistry, 97, 147-152.

2013

Denkova, AG, Terpstra, BE, Steinbach, I & Dam, J ten (2013). Adsorption of molybdenum on mesoporous aluminum oxides for potential application in nuclear medicine. Separation Science and Technology (Philadelphia), 48(9), 1331-1338.

Koleva, DA, Denkova, AG, Boshkov, N & Breugel, K van (2013). Electrochemical performance of steel in cement extract and bulk matrix properties of cement paste in the presence of pluronic 123 micelles. Journal of Materials Science, 48(6), 2490-2503.

Serra Crespo, P, Ostaay, HGME van, Denkova, AG, Wolterbeek, HT, Kapteijn, F & Gascon, J (2013). NH2-MIL-101 as adsorbent for potential application in nuclear medicine. In s.l. (Ed.), 17th International Zeolite Conference, Moscow, Russia (pp. 556-557). s.l.: s.n..

Serra Crespo, P, Ostaay, HGME van, Denkova, AG, Wolterbeek, HT, Kapteijn, F & Gascon, J (2013, juli 08). NH2-MIL-101 as adsorbent for potential application in nuclear medicine. Moscow, Russia, 17th International Zeolite Conference.

Steinebach, OM, Denkova, AG & Wolterbeek, HT   (13-06-2013). New column material and loading procedures for the loading and retention of 99-mo (mo mass) onto 99-mo-99m-tc generators. no 2007951.

Varini, M, Koleva, DA, Denkova, AG, Mol, JMC, Terryn, HA   & Breugel, K van (2013). Polymeric nano-materials for corrosion control of steel in concrete. In N de Belie, S van der Zwaag, E Gruyeart, K van Tittelboom & B Debbaut (Eds.), Proceedings of the Fourth International Conference on Self-healing Materials (pp. 254-258). Ghent, Belgium: Magnel Laboratory for Concrete Research.

Wang, G, Kruijff, RM de, Stuart, MCA, Mendes, E, Wolterbeek, HT   & Denkova, AG (2013). Polymersomes as radionuclide carriers loaded via active ion transport through the hydrophobic bilayer. Soft Matter, 9, 727-734.

Warman, JM  , Haas, MP de, Luthjens, LH, Denkova, AG, Kavatsyuk, O, Goethem, MJ van, Kiewiet, HH & Brandenburg, S (2013). Fixed fluorescent images of an 80 MeV proton pencil beam. Radiation Physics and Chemistry, 85, 179-181.

2012

Denkova, AG, Kruijff, R de, Wang, G, Mendes, E & Wolterbeek, HT (2012, november 08). Polymersomes as nano-carriers in nuclear medicin. University College, London, UK, International Conference on Nanotechnology in Medicine.

Denkova, AG, Kruijff, R de, Wang, G, Mendes, E & Wolterbeek, HT (2012, november 14). Polymersomes as nano-carriers in nuclear medicine. Bad Honnef, Germany, Juelich Soft Matter Days 2012.

Mendes, E, Denkova, AG, Bomans, PHH, Coppens, MO & Sommerdijk, NAJM (2012). The role of solvent - solvent correlations on complex morphologies of self-assembled block copolymers in binary solvent mixtures. Juelich Soft Matter Days 2012: Bad Honnef, Germany (2012, november 13 - 2012, november 16).

Thijssen, L, Schaart, DR  , De Vries, DJ, Morgenstern, A, Bruchertseifer, F & Denkova, AG (2012). Polymersomes as nano-carriers to retain harmful recoil nuclides in alpha radionuclide therapy: a feasibility study. Radiochimica Acta: international journal for chemical aspects of nuclear science and technology, 100, 473-481.

Wang, G, Kruijff, R de, Stuart, MCA, Mendes, E, Wolterbeek, HT   & Denkova, AG (2012). Polymersomes as radionuclide carriers loaded via active ion transport through the hydrophobic bilayer. Soft Matter, 9, 727-734.

Denkova, A. G.; Bomans, P. H. H.; Coppens, M.-O.; Sommerdijk, N. A. J. M.; Mendes, E.: Complex morphologies of self-assembled block copolymer micelles in binary solvent mixtures: the role of solvent-solvent correlations: Soft Matter 2011, 7, 6622-6628, DOI: 10.1039/c1sm05461a.

Denkova, A. G.; Mendes, E.; Coppens, M.-O.: Non-equilibrium dynamics of block copolymer micelles in solution: recent insights and open questions: Soft Matter 2010, 6, 2351-2357, DOI: 10.1039/c001175b.

Denkova, A. G.; Mendes, E.; Coppens, M.-O.: Rheology of worm-like micelles composed of tri-block copolymer in the limit of slow dynamics: J. Rheol. (Melville, NY, U. S.) 2009, 53, 1087-1100, DOI: 10.1122/1.3190170.

Jansen, D. R.; Zeevaart, J. R.; Denkova, A. G.; Kolar, Z. I.; Krijger, G. C.: Hydroxyapatite Chemisorption of N,N',N'-Trimethylenephosphonate-Poly(ethyleneimine) (PEI-MP) Combined with Sn2+ or Sn4+: Langmuir 2009, 25, 2790-2796, DOI: 10.1021/la802485g.

Denkova, A. G.; Mendes, E.; Coppens, M.-O.: Kinetics and Mechanism of the Sphere-to-Rod Transition of Triblock Copolymer Micelles in Aqueous Solutions: J. Phys. Chem. B 2009, 113, 989-996, DOI: 10.1021/jp807513k.

Denkova, A. G.; Mendes, E.; Coppens, M.-O.: Effects of Salts and Ethanol on the Population and Morphology of Triblock Copolymer Micelles in Solution: J. Phys. Chem. B 2008, 112, 793-801, DOI: 10.1021/jp075114c.

Norek, M.; Pereira, G. A.; Geraldes, C. F. G. C.; Denkova, A. G.; Zhou, W.; Peters, J. A.: NMR Transversal Relaxivity of Suspensions of Lanthanide Oxide Nanoparticles: J. Phys. Chem. C 2007, 111, 10240-10246, DOI: 10.1021/jp072288l.

Wierczinski, B.; Denkova, A. G.; Peters, J. A; Wolterbeek, H. T.: Kinetic stability of metal complexes - Determination of ka and kd using radiotracers. In Application of Radiotracers in Chemical, Enviromental and Biological Sciences; Lahiri, S., Nayak, D., Mukhopadhyay, A., Eds.; Saha Institute of Nuclear Physics: Kolkata, India, 2006; pp. 112-122.

Denkova, A. G.; Bouts, L. G.; Wierczinski, B.; Wolterbeek, H. T.; Breeman, W. A. P.; Peters, J. A. Determination of the kinetic stability of metal complexes with the Free Ion Selective Radiotracer Extraction. In Jahrestagung der GDCh-Fachgruppe Nuklearchemie München; Qaim, S. M.;  Coenen, H. H., Eds.,: Eurogress: Aachen, Germany, 2004.

Wierczinski, B.; Bouts, L. G.; Breeman, W. A. P.; Denkova, A. G.; Peters, J. A.; Wolterbeek, H. T.: Free-ion selective radiotracer extraction (FISRE) - a new technique to study the lability of metal complexes in radiopharmacy and environmental research. In Advances in Nuclear and Radiochemistry; Qaim, S. M.;  Coenen, H. H., Eds.: Forschungszentrum Julich GmbH.: Julich, Germany, 2004.

 

 

Name author: Yvon Weijgertse
© 2017 TU Delft

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